A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 39/395 (2006.01) A61K 31/496 (2006.01) A61K 31/7088 (2006.01) A61K 38/00 (2006.01) A61P 3/10 (2006.01) C12Q 1/00 (2006.01) C12Q 1/68 (2006.01) C12N 15/113 (2010.01) C07K 16/24 (2006.01)
Patent
CA 2563117
Methods of treating a mammal having type 1 diabetes or a risk for type 1 diabetes are provided. The methods comprise administering to the mammal a pharmaceutical composition comprising an agent that inhibits MIF in the mammal. Also provided are methods of evaluating whether a compound is useful for preventing or treating type 1 diabetes. The methods comprise determining whether the compound inhibits a macrophage migration inhibitory factor (MIF) in a mammal, then, if the compound inhibits the MIF, determining whether the compound inhibits development of type 1 diabetes.
L'invention concerne des méthodes de traitement d'un mammifère atteint du diabète de type 1 ou à risque pour le diabète de type 1. Ces méthodes comprennent l'administration audit mammifère d'une composition pharmaceutique comprenant un agent qui inhibe le facteur d'inhibition de la migration des macrophages. L'invention concerne aussi des procédés permettant d'évaluer si un composé est utile pour prévenir ou traiter le diabète de type 1. Ces procédés comprennent les étapes consistant à déterminer si le composé inhibe le facteur d'inhibition de la migration des macrophages chez un mammifère ; et, le cas échéant, à déterminer si ce composé inhibe le développement du diabète de type 1.
Osler Hoskin & Harcourt Llp
The Feinstein Institute For Medical Research
LandOfFree
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