Pyrrolo[1,2-b]pyridazine compounds and their use as crf1...

Details Pyrrolo[1,2-b]pyridazine compounds and their use as crf1... Pyrrolo[1,2-b]pyridazine compounds and their use as crf1...

C - Chemistry, Metallurgy

07

D

C07D 487/04 (2006.01) A61K 31/5025 (2006.01) A61P 25/00 (2006.01)

Patent

CA 2520900

Disclosed are novel CFR receptor antagonists and their use as treatment of a variety of disorders, including manifesting hypersercretion of CRF or associated with CRF or CRF receptors, such as anxiety, and depression. CRF receptor antagonists of the invention have the structure of formula (I) including stereoisomers or mixture of stereoisomers, pharmaceutically acceptable prodrugs, or pharmaceutically acceptable salts thereof, wherein in formula (I) R is H or Me.

L~invention concerne de nouveaux antagonistes des récepteurs du CRF et leur utilisation pour traiter une grande variété de troubles, notamment des troubles se manifestant par une hyper sécrétion du CRF ou bien associés au CRF ou à des récepteurs du CRF, tels que l~anxiété et la dépression. Les antagonistes décrits possèdent la structure répondant à la formule (I). L~invention concerne également leurs stéréoisomères ou un mélange de ceux-ci, leurs promédicaments pharmaceutiquement acceptables ou bien leurs sels pharmaceutiquement acceptables. Dans la formule (I), R est H ou Me.

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