Method and device for capsulating microbial, plant and...

B - Operations – Transporting – 01 – J

Patent

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B01J 13/04 (2006.01) A61K 9/16 (2006.01)

Patent

CA 2327716

The invention relates to a method for capsulating microbial, plant and animal cells or biological and chemical substances, using a nozzle to obtain small, especially spherical particles by vibrating an immobilisation mixture. According to said method, the immobilisation mixture, especially a laminar fluid jet taking the form of an immobilisation mixture, is divided into equal parts by superimposition of an external vibration. In a device especially well suited to carry out this method a metallic counter-element (18) which is mounted downstream from the nozzle (16) at a distance (a) to, and on the outside of, the nozzle axis (A) is connected to a high-voltage source (30). The counter-element is to be embodied by a metal ring (18) through whose through hole (20) the nozzle axis (A) extends. The metal ring (18) is radially connected to an insulated support (22, 24).

L'invention concerne un procédé pour encapsider des cellules microbiennes, végétales et animales ou bien des substances biologiques et chimiques, par l'intermédiaire d'une filière, dans de petites particules, notamment sphériques, par vibration d'un mélange d'immobilisation. Dans ce procédé, ce mélange d'immobilisation - et notamment un gel liquide laminaire sous forme de mélange d'immobilisation - est divisé en fractions de même grandeur par superposition d'une oscillation externe. Dans un dispositif particulièrement approprié à cet effet, un contre-élément (18) métallique placé en aval de la filière (16) à distance (a) et à l'extérieur de l'axe (A) de celle-ci est connecté à une source haute tension (30). Ce contre-élément doit se présenter sous la forme d'une bague métallique (18) dont l'orifice de passage (20) est traversé par l'axe de filière (A). Cette bague métallique (18) est raccordée radialement à une fixation (22, 24) isolée.

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