Indole-derived azylpiperazines as ligands for 5ht1-like...

Details Indole-derived azylpiperazines as ligands for 5ht1-like... Indole-derived azylpiperazines as ligands for 5ht1-like...

C - Chemistry, Metallurgy

07

D

C07D 403/02 (2006.01) A61K 31/495 (2006.01) C07D 209/16 (2006.01) C07D 405/14 (2006.01) C07D 409/12 (2006.01) C07D 409/14 (2006.01) C07D 413/12 (2006.01) C07D 413/14 (2006.01)

Patent

CA 2176935

Novel indole-derived azylpiperazines of general formula (I), wherein, inter alia, R1 is NH2 or NO2, R'1, R2, R'2, R3 and R4 are H, Z is -C- and X is 0. Methods for preparing such derivatives and the therapeutical uses thereof are also disclosed.

La présente invention concerne de nouvelles arylpipérazines dérivées d'indole correspondant à la formule générale (I), dans laquelle, notamment R1 = NH2 ou NO2; R1, R2, R'2, R3, R4 = H; Z = -C-, X = O R5 et R6 = H, alkyle, arylalkyle. Elle concerne également les procédés de préparation de ces dérivés ainsi que leur utilisation thérapeutique.

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