C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/57 (2006.01) A61Q 11/00 (2006.01) C11D 3/386 (2006.01) C12N 9/54 (2006.01) C12N 9/56 (2006.01) G02C 13/00 (2006.01)
Patent
CA 2170491
The present invention relates to subtilisin BPN' variants comprising at least one or more amino acid positions having a different amino acid than that occurring in wild-type subtilisin BPN' (i.e., substitution) at positions 199-220 whereby the BPN' variant has decreased adsorption to, and increased hydrolysis of, an insoluble substrate as compared to wild-type subtilisin BPN'.
La présente invention se rapporte à des variantes de BPN' de la subtilysine comprenant au moins une ou plusieurs positions d'acides aminés ayant un acide aminé différent de celui qui se trouve dans la BPN' de la subtilysine de phénotype sauvage (c.-à-d. de substitution) aux positions 199-220. Par rapport à la BPN' de la subtilysine de phénotype sauvage, la variante de BPN' présente une adsorption réduite sur un substrat insoluble et permet une meilleure hydrolyse de ce dernier.
Barnett Bobby Lee
Brode Philip Frederick III
Rubingh Donn Nelton
Kirby Eades Gale Baker
The Procter & Gamble Company
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