Spirofurane derivatives

Details Spirofurane derivatives Spirofurane derivatives

C - Chemistry, Metallurgy

07

D

C07D 491/107 (2006.01) A61K 31/445 (2006.01) C07D 491/10 (2006.01)

Patent

CA 2062809

2062809 9015804 PCTABS00003 Compounds of general formula (I), wherein R1 represents hydrogen or alkyl C1-3; R2 represents hydrogen, alkyl C1-6, alkenyl C3-6 or alkynyl C3-6; n and m are integers from 1 to 3, provided that n + m = 4, and one of X and Y represents CH2 and the other represents CHR3, C=CHR4 or C=NR5, in which R3, R4, R5, R6, R7, R8, R9, R10, R11 and R12 are as defined in the specification, and their salts are useful as pharmaceuticals, in particular as central muscarinic acetylcholine receptors. The compounds are therefore useful in the treatment of diseases such as presenile and senile dementia, Huntington's chorea, tardive dyskinesia, hyperkinesia, mania and Tourette Syndrome, and also as analgesic agents for use in the treatment of severe painful conditions such as rheumatism, arthritis, and terminal illness.

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