Novel carboxylic acid derivatives which carry amide side...

C - Chemistry – Metallurgy – 07 – D

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C07D 239/52 (2006.01) A61K 31/505 (2006.01) C07D 239/36 (2006.01) C07D 239/60 (2006.01) C07D 401/12 (2006.01)

Patent

CA 2307770

The invention relates to carboxylic acid derivatives of formula (I), wherein R6 represents a group (a) or (b), R13 and R14 being the same or different and having the following meaning: hydrogen; on the condition that R13 and R14 are not hydrogen at the same time, C1-C8-alkyl, C3-C8-cycloalkyl, C3-C8-alkenyl, C3-C8-alkinyl, benzyl, phenyl, naphthyl, optionally substituted; or R13 and R14 together form an optionally substituted C3-C7-alkylene chain which is closed in a ring and in which an alkylene group can be replaced by oxygen, sulphur or nitrogen; or R13 and R14 together form an optionally substituted C3- 7-alkylene chain or C3-C7-alkenylene chain which is closed in a ring and to which an optionally substituted phenyl ring is anellated. The other substituents have the meanings given in the description. The invention also relates to the production of the novel carboxylic acid derivatives and to their use as endothelin receptor antagonists.

La présente invention concerne des dérivés d'acide carboxylique de la formule (I), dans laquelle les substituents ont la signification qui est commentée dans la description. Elle porte aussi sur leur mode de production et leur utilisation en tant qu'antagonistes récepteurs d'endothéline.

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