C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/53 (2006.01) A61K 38/44 (2006.01) C12N 9/02 (2006.01) C12N 15/71 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2088574
The genes (sod) encoding Bacillus stearothermophi- lus and Bacillus caldotenax Mn-superoxide dismutase have been cloned in Escherichia coli and their entire nucleotide sequences determined. With the exception of the post- translationally cleaved N-terminal methionine residue, the predicted amino acid sequence of the B. stearothermophi- lus enzyme (BSMnSOD) exhibits 100 % similarity to the previously determined amino acid sequence. The B, caldoe- nax enzyme (BCMnSOD) differs by two amino acids from BSMnSOD. Both recombinant MnSOD's were shown to be functionally active in E. coli, both in vitro and in vivo, and were expressed to 47 % of the cells soluble protein by coup- ling their transcription to the E. coli trp promoter. The pharmaceutical use of these bacterial superoxide dismu- tases is described.
Atkinson Anthony
Bown Kevin J.
Brehm John K.
Chambers Stephen P.
Minton Nigel P.
Goudreau Gage Dubuc
Microbiological Research Authority Of Centre For Applied Microbi
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