Targeted oligonucleotide compositions for modifying gene...

Details Targeted oligonucleotide compositions for modifying gene... Targeted oligonucleotide compositions for modifying gene...

A - Human Necessities

61

K

A61K 31/7088 (2006.01) C12N 15/11 (2006.01)

Patent

CA 2726187

The invention comprises compositions and methods for modify-ing gene expression. Modified oligos of the invention restore the lost function of let- 7 wild type miRNA molecules that are prevented from silencing target genes by mutations occurring within their binding sites. Administration of a particular modified oligo (SEQ ID NO: 22) leads to increased cell death in can-cer cells carrying the LCS6 SNP.

L'invention concerne des compositions et des procédés permettant de modifier l'expression génique. Des oligos modifiés selon l'invention rétablissent la fonction perdue de molécules ARNmi de type sauvage let-7 qui sont empêchées d'éteindre les gènes cibles par des mutations survenant à l'intérieur de leurs sites de liaison. L'administration d'un oligo modifié particulier (SEQ ID NO: 22) conduit à une mort cellulaire accrue chez les cellules cancéreuses transportant LCS6 SNP.

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