Improved hmg coa reductase inhibitor extended release...

Details Improved hmg coa reductase inhibitor extended release... Improved hmg coa reductase inhibitor extended release...

A - Human Necessities

61

K

A61K 31/366 (2006.01) A61K 9/22 (2006.01) A61K 9/32 (2006.01) A61K 9/36 (2006.01) A61K 31/22 (2006.01)

Patent

CA 2315329

A controlled release dosage formulation is described which is based on a combination of: (a) a compressed tablet core which contains an alkyl ester of a hydroxy substituted naphthalene derivative, a pharmaceutically acceptable, water swellable polymer and an osmotic agent; and (b) an outer coating layer which completely covers the osmotic core and comprises a pH sensitive coating agent and a water insoluble polymer.

L'invention porte sur une préparation à libération contrôlée de doses basée sur une combinaison de: (a) un noyau fait d'un comprimé renfermant un ester alkylique d'un dérivé de naphtalène à substitution hydroxy, un polymère pharmacocompatible gonflant dans l'eau, et un agent osmotique; et (b) une couche extérieure d'enrobage recouvrant entièrement le noyau osmotique et renfermant un agent d'enrobage réagissant au pH ainsi qu'un polymère hydroinsoluble.

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