Method of modulating vascularization

Details Method of modulating vascularization Method of modulating vascularization

A - Human Necessities

61

K

A61K 48/00 (2006.01)

Patent

CA 2563304

A method of modulating vascularization in a tissue of a mammal comprises controlling a PAR signaling pathway (e.g., the PAR-1 or PAR-2 signaling pathway) in a mammalian tissue, for example, by controlling phosphorylation of tissue factor cytoplasmic domain (i.e., phosphorylation of Ser258 of the cytoplasmic tail of TF). In a preferred method pathological neovascularization in a mammal is treated by administering to a mammal suffering from pathological neovascularization, a therapeutically effective amount of a PAR signaling pathway inhibitor. Preferably the mammal is a human.

La présente invention concerne un procédé permettant de moduler la vascularisation d'un tissu chez un mammifère. En l'occurrence, on contrôle un chemin de signalisation PAR (par exemple le chemin de signalisation PAR-1 ou PAR-2) dans un tissu de mammifère, par exemple en contrôlant la phosphorylation du domaine cytoplasmique du facteur tissulaire, à savoir la phosphorylation du Ser258 de la queue cytoplasmique du facteur tissulaire. Selon u procédé préféré, pour traiter une néovascularisation pathologique chez un mammifère, on administre à ce mammifère une quantité thérapeutiquement suffisante d'un inhibiteur du chemin de signalisation PAR. Le mammifère est de préférence un humain.

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