C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 271/08 (2006.01) A61K 31/215 (2006.01) A61K 31/325 (2006.01) A61K 31/44 (2006.01) A61P 29/00 (2006.01) A61P 31/04 (2006.01) C07C 251/66 (2006.01) C07C 251/68 (2006.01) C07D 213/79 (2006.01)
Patent
CA 2653646
Provided are compounds of formula (I) and other compounds. Also provided are pharmaceutical compositions comprising these compounds. Additionally, methods of inhibiting macrophage migration inhibitory factor (MIF) activity in a mammal are provided, as are methods of treating or preventing inflammation in a mammal, and methods of treating a mammal having sepsis, septicemia, and/or endotoxic shock.
L'invention concerne des composés représentés par la formule (I) et d'autres composés. L'invention concerne également des compositions pharmaceutiques incluant ces composés. De plus, des procédés d'inhibition de l'activité du facteur inhibiteur de la migration des macrophages (MIF) chez un mammifère sont proposés, comme le sont des procédés de traitement ou de prévention de l'inflammation chez un mammifère, et des procédés de traitement d'un mammifère présentant une maladie infectieuse, une septicémie et/ou un choc endotoxique.
Osler Hoskin & Harcourt Llp
The Feinstein Institute For Medical Research
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