Granzyme b inhibitors

Details Granzyme b inhibitors Granzyme b inhibitors

C - Chemistry, Metallurgy

07

D

C07D 487/06 (2006.01) A61K 31/55 (2006.01) A61P 37/06 (2006.01) C07D 225/04 (2006.01) C07D 451/00 (2006.01) C07K 5/02 (2006.01) C07K 5/08 (2006.01) C07K 5/083 (2006.01) C07K 5/087 (2006.01) C07K 5/097 (2006.01) C07K 5/103 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2474917

The present invention encompasses compounds of Formula (I) and pharmaceutically acceptable salts or hydrates thereof. The compounds are inhibitors of granzyme B and are useful for treating autoimmune and chronic inflammatory diseases. Pharmaceutical compositions and methods of use are also included.

Composés de formule (I) et sels ou hydrates pharmaceutiquement acceptables desdits composés. Ces composés sont des inhibiteurs de granzyme B et sont utiles pour traiter des maladies autoimmunes et inflammatoires chroniques. La présente invention concerne également des compositions pharmaceutiques et des méthodes d'utilisation desdites compositions.

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