Therapeutic anti-hiv oligonucleotide and pharmaceutical

Details Therapeutic anti-hiv oligonucleotide and pharmaceutical Therapeutic anti-hiv oligonucleotide and pharmaceutical

C - Chemistry, Metallurgy

07

H

C07H 21/00 (2006.01) A61K 31/70 (2006.01) C12N 15/11 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2146364

Disclosed are oligonucleotides having nucleotide sequences that hybridize to at least nucleotides 324 to 348 of a conserved gag region of the HIV-1 genome. These oligonucleotides have about 25 to 30 nucleotides linked by at least one non-phosphodies- ter internucleotide linkage which render them resistant to nuclease digestion. Also disclosed are therapeutic formulations contain- ing such oligonucleotides and methods of inhibition HIV-1 proliferation and of treating HIV-1 infection in a mammal.

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