New aza-indolyl derivatives

Details New aza-indolyl derivatives New aza-indolyl derivatives

C - Chemistry, Metallurgy

07

D

C07D 487/14 (2006.01) A61K 31/44 (2006.01) C07D 471/14 (2006.01)

Patent

CA 2399111

The present invention refers to chemical compounds of formula (I) in which X1, X2, X3 and X4, n, R1, R2 and R3 and pharmaceutically acceptable salts and prodrugs thereof, and the use thereof in therapy, particularly for the treatment of disorders of the central nervous system; damage to the central nervous system; cardiovascular disorders; gastrointestinal disorders; diabetes insipidus, and sleep apnea, and particularly for the treatment of obesity.

La présente invention concerne des composés chimiques représentés par la formule (I), des sels et des promédicaments pharmaceutiquement acceptables de ceux-ci. Cette formule comprend X?1¿, X?2¿, X?3¿ et X?4¿, n, R?1¿, R?2¿ et R?3¿. Cette invention concerne aussi l'utilisation thérapeutique de ces composés, en particulier pour le traitement des troubles du système nerveux central, des dégradations du système nerveux central, des pathologies cardio-vasculaires, des troubles du système digestif, du diabète insipide, de l'apnée du sommeil et plus particulièrement pour le traitement de l'obésité.

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