Monoclonal antibodies to casein kinase i polypeptides

Details Monoclonal antibodies to casein kinase i polypeptides Monoclonal antibodies to casein kinase i polypeptides

C - Chemistry, Metallurgy

12

N

C12N 5/18 (2006.01) C07K 16/40 (2006.01) C12N 9/12 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2158750

Protein kinase mutant and wild-type genes encoding polypeptides of the class heretofore designated "casein kinase I" and useful in screening compositions which may affect DNA double-strand break repair activity are disclosed. Also disclosed are methods using the polynucleotides in cell-proliferative disorders.

Sont décrits des gènes mutants et de type sauvage de protéine-kinases codant pour des polypeptides de la classe dénommée "caséine-kinase I" et utiles dans des compositions de détection qui peuvent influer sur l'activité de réparation par recombinaison de l'ADN. Sont également décrits des procédés utilisant les polynucléotides dans des dérèglements prolifératifs cellulaires.

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