C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) C07K 14/47 (2006.01) C07K 16/18 (2006.01) C12N 5/10 (2006.01) C12N 15/11 (2006.01) C12N 15/63 (2006.01) G01N 33/566 (2006.01)
Patent
CA 2386596
The present invention is directed to novel polypeptides, nucleic acids and related molecules which have an effect on or are related to the cell cycle. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention. Further provided by the present invention are methods for identifying novel compositions which mediate cell cycle bioactivity, and the use of such compositions in diagnosis and treatment of disease.
La présente invention concerne des nouveaux polypeptides et acides nucléiques ainsi que des molécules associées agissant sur le cycle cellulaire ou en rapport avec le cycle cellulaire. L'invention concerne également des vecteurs et des cellules hôtes comprenant ces séquences d'acides nucléiques, des molécules de polypeptides chimériques comprenant les polypeptides de la présente invention fusionnés avec des séquences de polypeptides hétérologues, des anticorps se liant aux polypeptides de la présente invention et des méthodes de production desdits polypeptides. L'invention concerne en outre des méthodes d'idenfication de nouvelles compositions régulant la bioactivité du cycle cellulaire ainsi que l'utilisation de ces compositions dans le diagnostic et le traitement de maladies.
Fu C. Alan
Luo Ying
Shen Mary
Rigel Pharmaceuticals Inc.
Smart & Biggar
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