Pcv2 orf2 virus like particle with foreign amino acid insertion

Details Pcv2 orf2 virus like particle with foreign amino acid insertion Pcv2 orf2 virus like particle with foreign amino acid insertion

C - Chemistry, Metallurgy

12

N

C12N 15/866 (2006.01) A61K 39/002 (2006.01) A61K 39/145 (2006.01) A61K 39/385 (2006.01) C12N 7/01 (2006.01) C12N 15/00 (2006.01) C12N 15/86 (2006.01)

Patent

CA 2710558

The present invention comprises methods and compositions related to the production and use of amino acid se-quences. In particular, PCV2 ORF2 is shown to be useful as a virus-like particle which produces amino acid sequences that retain their immunogenicity or antigenicity when the DNA encoding the PCV2 ORF2 is inserted into an expression system. DNA se-quences that are foreign to PCV2 can be attached 'in- frame' to the ORF2 DNA and the entire sequence, including the DNA foreign to PCV2, is expressed. It was shown that such sequences retain their antigenicity and therefore their potential utility in immuno-genic compositions.

La présente invention concerne des procédés et des compositions associés à la production et l'utilisation de séquences d'acides aminés. En particulier, la présente invention concerne le PCV2 ORF2 utile en tant que particule de type virus qui produit des séquences d'acides aminés qui préservent leur immunogénicité ou antigénicité lorsque l'ADN codant pour le PCV2 ORF2 est introduit dans un système d'expression. Les séquences d'ADN qui sont étrangères au PCV2 peuvent se fixer « en cadre » à l'ADN d'ORF2 et la séquence entière, comprenant l'ADN étranger au PCV2, est exprimée. Il a été démontré que de telles séquences retiennent leur antigénicité et donc leur utilité potentielle dans des compositions immunogènes.

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