C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 7/50 (2006.01) A61K 38/19 (2006.01) A61K 38/22 (2006.01) A61K 39/395 (2006.01) A61P 29/00 (2006.01) A61P 35/00 (2006.01) A61P 37/00 (2006.01) C07K 1/107 (2006.01)
Patent
CA 2578592
Conformationally constrained peptides that mimic BH3-only proteins and their conjugation to antibodies and other cell targeting compounds, compositions containing the conjugates and their use in the regulation of cell death are disclosed. The conformationally constrained peptides are capable of binding to and neutralising pro-survival Bcl-2 proteins. Processes for preparing the conformationally constrained peptides conjugated to antibodies and other cell targeting compounds and use of the conjugates in the treatment and/or prophylaxis of diseases or conditions associated with deregulation of cell death are also disclosed.
La présente invention concerne des peptides à conformations contraintes, présentant un mimétisme avec protéines BH3 seules. L'invention concerne également leur conjugaison à des anticorps et à d'autres composés ciblant des cellules, des compositions contenant ces conjugués, et leur utilisation dans la régulation de la mort cellulaire. Ces peptides sont capables de se lier à des protéines Bcl-2 et d'en neutraliser la pro-survie. L'invention concerne aussi des procédés permettant l'élaboration de tels peptides conjugués à des anticorps et à d'autres composés ciblant des cellules, et l'utilisation de ces conjugués pour le traitement et/ou la prévention d'affections ou d'états en liaison avec la dérégulation de la mort cellulaire.
Baell Jonathan
Scanlon Denis Bernard
Wei Andrew Henry
Fetherstonhaugh & Co.
The Walter And Eliza Hall Institute Of Medical Research
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