Stress proteins and peptides and methods of use thereof

Details Stress proteins and peptides and methods of use thereof Stress proteins and peptides and methods of use thereof

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) A61K 38/17 (2006.01) A61P 37/00 (2006.01) C07K 14/00 (2006.01) C07K 14/35 (2006.01) C07K 14/47 (2006.01) C07K 16/18 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2418445

Provided are HLA pan DR peptide and methods of using such peptides to modulate, block, or inhibit immune responses in treatment of immune-mediated diseases and conditions, such as inflammatory and autoimmune diseases, cancer, and microbial infections. The peptides and methods are useful diagnostically to screen peptide or peptide analogs that can inhibit the pathogenic immune response or upregulate an immune response against aberrant or invading cells, to monitor efficacy or therapeutic use and to identify other agents that may be effective to inhibit or modulate the immune response.

Cette invention concerne des peptides HLA pan DR et des méthodes d'utilisation desdits peptides pour moduler, bloquer ou inhiber les réponses immunitaires dans le cas de maladies et de troubles d'origine immunologique telles que les maladies inflammatoires et auto-immunes, le cancer et les infections microbiennes. Ces peptides et leurs méthodes d'utilisation sont utiles sous l'angle du diagnostic pour cribler des peptides ou des analogues peptidiques qui sont capables d'inhiber la réponse immunitaire pathogène ou de réguler à la hausse une réponse immunitaires contre des cellules aberrantes ou envahisseuses, pour contrôler l'efficacité ou l'utilisation thérapeutique et identifier d'autres agents pouvant inhiber ou moduler efficacement la réponse immunitaire.

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