Polynucleotide vaccine formulation against pathologies of...

A - Human Necessities – 61 – K

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A61K 48/00 (2006.01) A61K 31/70 (2006.01) A61K 39/295 (2006.01) C07K 14/03 (2006.01) C07K 14/11 (2006.01) C07K 14/33 (2006.01)

Patent

CA 2260858

Disclosed and claimed is: an immunogenic or vaccine composition for inducing in an equine host an immunological response against equine pathologies containing at least one plasmid that contains and expresses in vivo in an equine host cell nucleic acid molecule(s) having sequence(s) encoding antigen(s) of the equine pathogen(s); and, methods for using and kits employing such compositions.

La formule de vaccin contre des pathologies des équidés et notamment des chevaux, comprenant au moins 3 valences de vaccin polynucléotidique comprenant chacune un plasmide intégrant, de manière à l'exprimer in vivo dans les cellules hôtes, un gène d'une valence de pathogène équin, ces valences étant choisies parmi celles du groupe consistant en virus de la rhinopneumonie équine EHV, virus de la grippe équine EIV et anatoxine de la toxine tétanique, ces plasmides comprenant, pour chaque valence, un ou plusieurs des gènes choisis parmi le groupe consistant en gB et gD pour le virus de la rhinopneumonie équine, HA, NP, N pour le virus de la grippe équine et un gène codant pour tout ou partie de la sous-unité C de Cl. tetani.

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