Pharmaceutical compositions comprising cyclosporin

Details Pharmaceutical compositions comprising cyclosporin Pharmaceutical compositions comprising cyclosporin

A - Human Necessities

61

K

A61K 9/00 (2006.01) A61K 9/127 (2006.01) A61K 38/13 (2006.01)

Patent

CA 2639696

The invention relates to liquid pharmaceutical compositions containing: a) a therapeutically effective dose of a cyclosporin; b) an aqueous carrier liquid; c) a first solubilizing substance selected among the group of phospholipids; and d) a second solubilizing substance selected among the group of non-ionic surfactants. Preferably, the cyclosporin is liposome solubilized. The inventive composition is suitable for oral, parenteral, nasal, mucosal, topical, and particularly pulmonary application in the form of an aerosol.

L'invention concerne des compositions pharmaceutiques fluides, contenant : (a) une dose thérapeutiquement efficace de cyclosporine, (b) un excipient liquide aqueux, (c) une première substance améliorant la solubilité sélectionnée dans le groupe des phospholipides et (d) une seconde substance améliorant la solubilité sélectionnée dans le groupe des tensioactifs non ioniques. La cyclosporine est de préférence solubilisée sous forme liposomale. Cette composition peut être administrée par voie orale, parentérale, nasale, mucosale, topique et en particulier par voie pulmonaire sous la forme d'un aérosol.

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