C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 5/065 (2006.01) C07C 277/08 (2006.01) C07C 279/24 (2006.01) C07F 7/10 (2006.01) C07K 5/06 (2006.01)
Patent
CA 2250583
The present invention relates to a novel process for preparing N-methyl-D- phenylalanyl-N-[1-[3-[(aminoiminomethyl)amino]propyl]-3,3-difluoro-2-oxohexyl]- L-prolinamide or a pharmaceutically acceptable salt therof and to a key intermediate by directly guanylating Dakin-West intermediates.
Cette invention a trait à un nouveau procédé de préparation de N-méthyl-D-phénylalanyl-N-[1-[3-[(aminoiminométhyl)amino]propyl]-3,3-difluoro-2-oxohexyl]-L-prolinamide ou d'un sel de cette substance, acceptable du point de vue pharmaceutique. Elle concerne également un intermédiaire décisif obtenu par la guanylation directe d'intermédiaires de Dakin-West.
Aventis Pharmaceuticals Inc.
Hoechst Marion Roussel Inc.
Osler Hoskin & Harcourt Llp
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