A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/5585 (2006.01) A61K 31/34 (2006.01) A61K 31/557 (2006.01) A61K 45/06 (2006.01) A61P 9/12 (2006.01)
Patent
CA 2412856
The invention relates to pharmaceutical compositions for the treatment of pulmonary arterial hypertension comprising a prostacyclin or a prostacyclin analogue, preferably epoprostenol, and an endothelia receptor antagonist, preferably bosentan. The invention further provides methods for treating a subject suffering from pulmonary arterial hypertension using the compositions of the invention. The concomitant administration of prostacyclin or a prostacyclin analogue and an endothelia receptor antagonist not only increases the efficacy compared to administration of each alone but also reduces the side effects associated with prostacyclin or prostacyclin analogues.
Actelion Pharmaceuticals Ltd
Gowling Lafleur Henderson Llp
LandOfFree
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