Preparations containing silicon dioxide to improve the taste...

A - Human Necessities – 61 – K

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A61K 47/04 (2006.01) A61K 9/00 (2006.01) A61K 9/14 (2006.01) A61K 9/18 (2006.01) A61K 9/20 (2006.01) A61K 31/135 (2006.01) A61K 31/44 (2006.01)

Patent

CA 2160368

A chewable cold/sinus preparation comprising a bitter tasting mixture of a decongestant such as pseudoephedrine and an antihistamine such as diphenhydramine and/or chlorpheniramine maleate is made with no bitter, metallic taste or unpleasant mouthfeel by adsorbing the active drug mixture using a wet granulation process onto a silicon dioxide carrier which comprises from about 50 to about 85 % of total weight of the adsorbate composition. A truly multi-symptom relief formula is prepared through the optional addition of an antitussive such as dextromethorphan hydrobromide and/or an analgesic such as meclofenamic acid, aspirin or ibuprofen. Additional excipients such as flavors, sweeteners, lubricants and bulk fillers are added for better taste, improved mouthfeel and as an aid to the tabletting process.

Préparation à mastiquer contre les sinusiteset les rhumes, contenant un mélange amer d'un décongestionnant tel que la pseudoéphédrine et d'un antihistaminique tel qu'un maléate de diphénhydramine et/ou de chlorphéniramine dont l'amertume, le goût métallique ou la sensation en bouche déplaisants sont éliminés par adsorption du mélange médicamenteux actif sur un excipient de silice représentant entre 50 à environ 85 % en poids de l'ensemble, au moyen d'un procédé de granulation par voie humide. On obtient une formule soulageante vraiment polyvalente par adjonction facultative d'un antitussif tel que le bromure hydraté de dextrométhorphane et/ou d'un analgésique tel que l'acide méclofénamique, l'aspirine ou l'ibuprofène. On incorpore également d'autres excipients tels que des arômes, des édulcorants, des lubrifiants et des charges de volume pour améliorer le goût et la sensation en bouche et faciliter la confection des comprimés.

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