A synthetic peptide disturbing intracellular signaling

Details A synthetic peptide disturbing intracellular signaling A synthetic peptide disturbing intracellular signaling

C - Chemistry, Metallurgy

07

K

C07K 5/04 (2006.01) C07K 7/06 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2362464

The present invention related to composition and methods for treating cancer. The invention provides peptides derived from small modular domains that are SH2 and SH3 motifs. These domains play critical roles in protein-protein interaction that are important for intracellular location, recruitment of substrates prior to prophosphorylation, redistribution of substrates to receptor complexes, and inactivation or activation of catalytic activity. For intracellular translocation and cancer targeting, these peptides were conjugated with palmitic acid which was previously used to these approaches. The invention is useful for inhibiting signal pathway in cancer cells such as hepatocellular carcinoma, cervical cancer, colon adenocarcinoma, and fibrosacoma.

L'invention porte sur des compositions et procédés de traitement du cancer et sur des peptides dérivant de petits domaines modulaires tels que les motifs SH2 et SH3. Lesdits domaines jouent un rôle critique dans les interactions protéine-protéine importantes pour les localisations intracellulaires, pour la sélection de substrat avant la prophosphorylation, pour la redistribution de substrats aux complexes récepteurs, et pour l'inactivation ou l'activation de l'activité catalytique. Pour la translocation intracellulaire et le ciblage du cancer, ces peptides sont associés à de l'acide palmitique utilisé précédemment à ces fins. L'invention inhibe le mécanisme de signalisation dans les cellules cancéreuses par exemple celles du carcinome hépatocellulaire, du cancer du col de l'utérus, de l'adénocarcinome du colon, et du fibrosarcome.

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