Antibodies to madcam

Details Antibodies to madcam Antibodies to madcam

A - Human Necessities

61

K

A61K 48/00 (2006.01) A61K 49/00 (2006.01) C07K 16/30 (2006.01) C12N 5/12 (2006.01)

Patent

CA 2552523

The present invention relates to antibodies including human antibodies and antigen-binding portions thereof that specifically bind to MAdCAM, preferably human MAdCAM and that function to inhibit MAdCAM. The invention also relates to human anti-MAdCAM antibodies and antigen-binding portions thereof. The invention also relates to antibodies that are chimeric, bispecific, derivatized, single chain antibodies or portions of fusion proteins. The invention also relates to isolated heavy and light chain immunoglobulins derived from human anti-MAdCAM antibodies and nucleic acid molecules encoding such immunoglobulins. The present invention also relates to methods of making human anti-MAdCAM antibodies, compositions comprising these antibodies and methods of using the antibodies and compositions for diagnosis and treatment. The invention also provides gene therapy methods using nucleic acid molecules encoding the heavy and/or light immunoglobulin molecules that comprise the human anti-MAdCAM antibodies. The invention also relates to transgenic animals or plants comprising nucleic acid molecules of the invention.

La présente invention concerne des anticorps, y compris les anticorps humains et leurs parties se liant aux antigènes, qui se lient nommément aux MAdCAM, de préférence aux MAdCAM humaines, et qui fonctionnent de manière à inhiber les MAdCAM. L'invention concerne aussi des anticorps humains anti-MAdCAM et leurs parties se liant spécifiquement aux antigènes. Elle concerne également des anticorps qui sont des anticorps chimères, bispécifiques, dérivatisés, à chaîne unique ou des parties de protéines de fusion. L'invention concerne ensuite des immunoglobulines isolées à chaîne lourde ou légère, dérivés à partir des anticorps humains anti-MAdCAM et de molécules d'acides nucléiques codant ces immunoglobulines. La présente invention concerne aussi des procédés de fabrication d'anticorps humains anti-MAdCAM, des compositions comprenant ces anticorps et des procédés d'utilisation de ces anticorps et compositions pour le diagnostic et le traitement. L'invention concerne également des procédés de thérapie génique utilisant des molécules d'acides nucléiques codant pour des molécules lourdes et/ou légères d'immunoglobuline qui comprennent des anticorps anti-MAdCAM. L'invention concerne enfin des animaux ou plantes transgéniques comprenant des molécules d'acides nucléiques de l'invention.

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