Process for preparing mono-n-alkylated polyazamacrocycles

Details Process for preparing mono-n-alkylated polyazamacrocycles Process for preparing mono-n-alkylated polyazamacrocycles

C - Chemistry, Metallurgy

07

D

260/237.2

C07D 255/02 (2006.01) C07D 257/02 (2006.01) C07D 259/00 (2006.01) C07D 403/06 (2006.01) C07D 487/08 (2006.01)

Patent

CA 2006358

The invention relates to a novel process to prepare selectively mono-N-alkylated polyazamacrocycles which requies a electrophile with between one and five equivalents of a suitable macrocycle in a solvent which will not promote a proton transfer.

L'invention porte sur un procédé innovateur pour préparer sélectivement des polyazamacrocycles mono-N-alkylés qui exige un électrophile avec entre un et cinq équivalents d'un macrocycle approprié dans un solvant qui ne favorisera pas un transfert de protons.

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