Methods and compositions useful for stimulating an immune...

Details Methods and compositions useful for stimulating an immune... Methods and compositions useful for stimulating an immune...

C - Chemistry, Metallurgy

12

N

C12N 7/01 (2006.01) A61K 39/00 (2006.01) A61K 39/245 (2006.01) C12N 7/04 (2006.01) C12N 15/86 (2006.01) C07K 14/045 (2006.01) C07K 14/52 (2006.01) C07K 14/715 (2006.01) C12N 15/19 (2006.01) C12N 15/38 (2006.01)

Patent

CA 2437201

The invention provides compositions containing modified cytomegalovirus, and methods of using the compositions. In various embodiments, the modifications include adding a heterologous sequence encoding a non-viral chemokine element and/or immunogenic polypeptide, and/or disabling a viral dissemination gene.

L'invention concerne des compositions contenant des cytomégalovirus modifiés, ainsi que des procédés d'utilisation de ces compositions. Dans divers modes de réalisation, les modifications consiste à ajouter une séquence hétérologue codant un élément de chimiokine non virale et/ou un polypeptide immunogène, et/ou à inhiber un gène de dissémination virale.

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