Cyclic urea derivatives, pharmaceutical compositions...

C - Chemistry – Metallurgy – 07 – D

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C07D 403/04 (2006.01) A61K 31/55 (2006.01) C07D 223/16 (2006.01) C07D 401/14 (2006.01) C07D 403/14 (2006.01) C07D 405/14 (2006.01)

Patent

CA 2197789

The present invention relates to cyclic urea derivatives of general formula (see formula I) wherein, R1 to R9, R a, R b, A, D, E and F are as defined in claim 1, the tautomers thereof, the stereoisomers thereof, including the mixtures and salts thereof, particularly the physiologically acceptable salts with inorganic or organic acids or bases, which have, inter alia, valuable pharmacological properties, preferably aggregation-inhibiting effects, and to pharmaceutical compositions containing these compounds, the use thereof and processes for preparing them.

Les dérivés cycliques d'urée ayant la formule générale (I), dans laquelle R1 à R9, Ra, Rb, A, D, E et F ont la définition donnée dans la première revendication, leurs tautomères, leurs stéréoisomères, y compris leurs mélanges et leurs sels, notamment leurs sels physiologiquement admissibles avec des acides ou des bases inorganiques ou organiques, ont de précieuses propriétés pharmacologiques et autres, de préférence un effet inhibiteur de l'agrégation. L'invention concerne également des médicaments qui contiennent ces composés, leur utilisation et leur procédé de préparation.

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