Somatotropin modifications

Details Somatotropin modifications Somatotropin modifications

C - Chemistry, Metallurgy

07

K

C07K 14/61 (2006.01) A61K 38/27 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2145546

Somatotropin modifications are described that have unexpected enhancements in conformational and chemical stability without loss of bioactivity. Alterations of these characteristics are obtained via modification of somatotropins by site-directed mu- tagenesis. These changes increase the storage stability of these proteins. Exemplary modifications include poreine somatotropins having histidine and arginine substitutions for glutamine and histidine at positions 19 and 20, respectively (Q19H, H20R), having glutamic acid substituted for phenylalanine at position 52 (F52E), and having glutamic acid substituted for leucine at position 137 (1137E). The modified somatotropins are useful to enhance growth characteristics in animal species, e.g., to increase the lean- to-fat ratio in pigs and milk production in cows.

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