Carbazole derivatives as functional 5-ht6 ligands

Details Carbazole derivatives as functional 5-ht6 ligands Carbazole derivatives as functional 5-ht6 ligands

C - Chemistry, Metallurgy

07

D

C07D 209/88 (2006.01) A61K 31/403 (2006.01) A61P 25/00 (2006.01)

Patent

CA 2626646

The present invention provides carbazole derivatives of formula (I), useful in treatment of a CNS disorders related to or affected by the 5-HT6 receptor. Pharmacological profile of these compounds includes high affinity binding with 5-HT6 receptor along with good selectivity towards the said receptor. The present invention also includes the stereoisomers, the salts, methods of preparation and medicines containing the said carbazole derivatives.

L'invention concerne des dérivés de carbazole représenté par la formule (I) utile dans le traitement de troubles du système nerveux central liés au récepteur 5-HT6 ou dus à ce dernier. Le profil pharmacologique de ces composés comprend une liaison à affinité élevée avec le récepteur 5-HT6 ainsi qu'une bonne sélectivité envers ledit récepteur. L'invention concerne également les stéréoisomères, les sels, les méthodes de préparation et les médicaments contenant lesdits dérivés de carbazole.

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