Plant extracts for the treatment of increased bone resorption

Details Plant extracts for the treatment of increased bone resorption Plant extracts for the treatment of increased bone resorption

A - Human Necessities

61

K

A61K 38/04 (2006.01) A61K 38/05 (2006.01)

Patent

CA 2546180

The present invention concerns the use of .gamma.-glutamyl-peptide, for example .gamma. -L- glutamyltrans-S-1-propenyl-L-cysteine sulfoxide, in the treatment or prevention of diseases or conditions which are characterized by increased bone resorption, such as Paget's disease, tumor-induced bone disease or osteoporosis, inhibits dose-dependently the resorption activity of osteoclasts, the minimal effective dose being about 2 mM.

L'invention concerne l'utilisation d'un .gamma.-glutamyl-peptide, par exemple .gamma.-L-glutamyl-trans-S-1-propényl-L-cystéine sulfoxyde, afin de traiter ou de prévenir des maladies ou des états caractérisés par une augmentation de la résorption osseuse, tels que la maladie de Paget, la maladie osseuse provoquée par une tumeur ou l'ostéoporose, ce qui consiste à inhiber sur une base de dosage l'activité de résorption des ostéoclastes, la dose minimale efficace étant d'environ 2 mM.

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