Crf analogs

Details Crf analogs Crf analogs

C - Chemistry, Metallurgy

07

K

C07K 14/575 (2006.01) A61K 38/22 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2075718

Analogs of CRF, which are based upon rCRF, oCRF, sauvagine and alpha-helical CRF, are disclosed that can be admin- istered to achieve a substantial elevation of ACTH, .beta.-endorphin, .beta.- lipotropin, other products of the pro-opiomelanocortin gene and cortieosterone levels and/or an increase in blood pressure over an extended period of time. One analog which has been found to be particularly potent is: H-D-Pro-Pro-Ile-Ser-Leu-Asp-Leu-Thr-D-Phe- His-Leu-Leu-Arg-Glu-Val-Leu-Glu-Nle-Ala- Arg-Ala-Glu-Gln-Leu-Ala-Gln-Gln-Ala-His-Ser-Asn-Arg-Lys-CML-Nle-Glu-Ile-Ile- NH2. In the analogs of the native 41-resi- due polypeptides, one or more of the first six N-terminal residues may be deleted and/or the N-terminal alpha-amino group may be acylated by an acylating agent containing up to 7 carbon atoms. A number of other substitutions may also be made throughout the chain. These analogs or pharmaceutically or veterinarily acceptable salts thereof, dispersed in a pharmaceut- ically or veterinacily acceptable liquid or solid carrier; can be administered to mammals, including humans. These analogs may also be used as stimulants to elevate mood and improve memory and learning, as well as diagnostically.

Affiliated with

Also associated with

Rating

Crf analogs does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Crf analogs, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Crf analogs will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1559029