Antiviral nucleoside derivatives

Details Antiviral nucleoside derivatives Antiviral nucleoside derivatives

C - Chemistry, Metallurgy

07

H

C07H 19/167 (2006.01) A61K 31/70 (2006.01) A61P 31/14 (2006.01)

Patent

CA 2504846

The present invention relates to nucleoside derivatives for the treatment of Hepatitis C viral infections including compounds of formula I (I), to pharmaceutical compositions comprising these compounds and methods for treatment or prophylaxis of Hepatitis C Virus mediated diseases employing said compounds in monotherapy or in combination therapy. The present invention further provides a process for preparing 1',3',4'-triacyl pyrimidine nucleoside from a N,1',3',4'-tetraacylpyrimidine nucleoside.

La présente invention concerne des dérivés nucléosidiques destinés au traitement d'infections par le virus de l'hépatite C, y compris des composés représentés par la formule générale (I), des compositions pharmaceutiques comprenant ces composés et des méthodes destinées au traitement ou à la prévention de maladies induites par le virus de l'hépatite C faisant intervenir ces composés en monothérapie ou en polythérapie. La présente invention concerne également un procédé destiné à la préparation d'un nucléoside de 1',3',4'-triacyl pyrimidine à partir d'un nucléoside de N,1',3',4'-tétraacylpyrimidine.

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