Molecules that home to a selected organ or tissue in vivo...

Details Molecules that home to a selected organ or tissue in vivo... Molecules that home to a selected organ or tissue in vivo...

C - Chemistry, Metallurgy

07

K

C07K 7/06 (2006.01) A61K 39/395 (2006.01) A61K 47/48 (2006.01) A61K 49/00 (2006.01) A61K 51/08 (2006.01) A61K 51/10 (2006.01) C07K 1/04 (2006.01) C07K 1/22 (2006.01) C07K 4/00 (2006.01) C07K 7/08 (2006.01) C07K 14/00 (2006.01) C12Q 1/68 (2006.01) G01N 33/554 (2006.01) G01N 33/567 (2006.01)

Patent

CA 2204535

The present invention provides an in vivo method for identifying molecules that home to a selected organ or tissue. In addition, the invention provides peptides that home to a selected organ or tissue. For example, the invention provides peptides that selectively home to an organ such as brain or kidney or to a tissue such as a tumor tissue. The invention further provides methods of using an organ homing molecule, for example, to target an agent such as a drug to a selected organ or to identify the target molecule expressed by the selected organ. The invention also provides methods of targeting an organ or tissue containing angiogenic vasculature by contacting the organ or tissue with a molecule that specifically binds an .alpha.v-containing integrin.

Procédé in vivo d'identification de molécules qui se dirigent vers un organe ou des tissus choisis. La présente invention concerne en outre des peptides qui se dirigent vers un organe ou des tissus choisis. Par exemple, elle porte sur des peptides qui se dirigent sélectivement vers un organe tel que le cerveau ou le rein ou vers des tissus tels qu'une tumeur. La présente invention concerne encore des procédés d'utilisation d'une molécule se dirigeant vers un organe, par exemple pour cibler un agent tel qu'un médicament vers un organe choisi ou pour identifier la molécule cible exprimée par l'organe choisi. Elle concerne enfin des procédés de ciblage d'un organe ou de tissus contenant un système vasculaire angiogénique par mise en contact dudit organe ou desdits tissus avec une molécule qui se lie spécifiquement à une intégrine contenant .alpha.¿v?.

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