Process for the preparation of halogenated benzoic acids

C - Chemistry – Metallurgy – 07 – C

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C07C 63/70 (2006.01) C07C 37/60 (2006.01) C07C 39/27 (2006.01) C07C 41/26 (2006.01) C07C 43/23 (2006.01) C07C 51/285 (2006.01) C07C 51/34 (2006.01) C07C 201/14 (2006.01) C07C 205/58 (2006.01) C07C 229/54 (2006.01) C07C 255/57 (2006.01) C07C 317/44 (2006.01)

Patent

CA 2110085

Abstract of the Disclosure A process for the preparation of halogenated benzoic acids of formula (1): Image (1) in which R1, R2, R3, R4 and R5 are hydrogen, fluorine, chlorine or bromine atoms or C1-C6-alkyl, C1-C6-alkoxy, nitro, cyano, trifluoromethyl, aldehyde, C1-C4-alkoxy- carbonyl, -SO2-C1-C4-alkyl, -SO2-phenyl, -CONH2, -CON(C1-C4- alkyl)2, hydroxy, carboxy, -NH2 or -N(C1-C4- alkyl)2 groups, at least one of the substituents R1 - R5 being one of said halogen atoms, which comprises reacting 1 mol of a benzophenone, asymmetrically substituted on the benzene rings A and B, of general formula (2): Image (2) in which R1 - R10 are as defined above for R1 - R5, with about 1 to about 10 mol of an oxidizing agent selected from the group comprising hydrogen peroxide, urea/hydrogen peroxide addition product, an alkali metal peroxide, ammonium, alkali metal or alkaline earth metal peroxodisulfates, pertungstates, perborates or percarbonates, ozone, alkyl- or aryl-percarboxylic acids, alkyl- or aryl-persulfonic acids or persulfuric acid, at temperatures from about -20° to about +100°C.

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