Transport protein which is used to introduce chemical...

Details Transport protein which is used to introduce chemical... Transport protein which is used to introduce chemical...

C - Chemistry, Metallurgy

07

K

C07K 14/33 (2006.01)

Patent

CA 2578097

The invention relates to a transport protein which can be obtained by modifying the heavy chain of the neurotoxin formed by Clostridium botulinum. The protein binds specifically to nerve cells with a higher affinity as the native neurotoxin. The invention also relates to a method for the production of transport protein, the nucleic acids coding for the transport protein, the transport protein containing pharmaceutical and cosmetic compositions and use thereof.

Protéine de transport obtenue par modification de la chaîne lourde de la neurotoxine produite par Clostridium botulinum, ladite protéine se liant spécifiquement à des cellules nerveuses, avec une affinité plus élevée que la neurotoxine native. La présente invention concerne en outre un procédé de production de ladite protéine de transport, des acides nucléiques codant pour cette protéine de transport, des compositions pharmaceutiques et cosmétiques contenant cette protéine de transport et l'utilisation desdites compositions.

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