Tetrahydropyranyl cyclopentyl benzylamide modulators of...

Details Tetrahydropyranyl cyclopentyl benzylamide modulators of... Tetrahydropyranyl cyclopentyl benzylamide modulators of...

C - Chemistry, Metallurgy

07

D

C07D 498/04 (2006.01) A61K 31/165 (2006.01) A61K 31/195 (2006.01) A61K 31/343 (2006.01) A61K 31/351 (2006.01) A61K 31/352 (2006.01) A61K 31/381 (2006.01) A61K 31/407 (2006.01) A61K 31/41 (2006.01) A61K 31/416 (2006.01) A61K 31/427 (2006.01) A61K 31/4468 (2006.01) A61K 31/453 (2006.01) A61K 31/5383 (2006.01) C07C 233/57 (2006.01) C07D 211/58 (2006.01) C07D 211/96 (2006.01) C07D 257/04 (2006.01) C07D 263/48 (2006.01) C07D 277/26 (2006.01) C07D 305/08 (2006.01) C07D 307/22 (2006.01) C07D 307/93 (2006.01) C07D

Patent

CA 2502174

The present invention is directed to compounds of the formula (I) (wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, R27, R28, R29, R30, R31, X, m, n and the dashed line are defined herein) which are useful as modulators of chemokine receptor activity. In particular, these compounds are useful as modulators of the chemokine receptor CCR-2.

La présente invention concerne des composés représentés par la formule générale (I). Dans cette formule, R?1¿, R?2¿, R?3¿, R?4¿, R?5¿, R?6¿, R?7¿, R?8¿, R?9¿, R?10¿, R?11¿, R?27¿, R?28¿, R?29¿, R?30¿, R?31¿, X, m, n et la ligne en pointillés sont tels que définis dans les spécifications. Ces composés conviennent particulièrement comme modulateurs de l'activité des récepteurs de la chimiokine et plus particulièrement du récepteur CCR-2.

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