Use of prophenytoin for treating stroke

Details Use of prophenytoin for treating stroke Use of prophenytoin for treating stroke

A - Human Necessities

61

K

167/237

A61K 31/415 (2006.01) A61K 31/675 (2006.01)

Patent

CA 2022842

ABSTRACT The present invention relates to novel therapeutic use of known derivatives of phenytoin or stable pharmaceutical composition of the phenytoin prodrug which is now known as fosphenytoin sodium. More particularly, the present invention concerns a method of treating stroke in a human at risk of or suffering from stroke comprising administration of the derivatives of phenytoin, preferably 3-(hydroxy- methyl)-5,5-diphenylhydantoin phosphate ester disodium salt, a prodrug of phenytoin or the stable pharmaceutical composition of this prodrug. This compound is also variously known as the fosphenytoin sodium; 5,5-diphenyl-3-[(phosphonooxy)methyl]- 2,4-imidazolidinedione disodium salt; 3-phosphoryl- oxymethyl-5,5-diphenylhydantoin disodium salt; or 3-(hydroxymethyl)-5,5-diphenylhydantoin disodium phosphate ester.

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