Method of cell inhibition using polypeptides derived from...

C - Chemistry – Metallurgy – 07 – K

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C07K 14/435 (2006.01) A61K 38/17 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2266336

An isolated polypeptide having cytotoxic activity comprising the amino acid sequence of Pilosulin 1 shown in the figure, an active portion thereof, or a functionally equivalent amino acid sequence thereof, and a method of inhibiting the growth of a cell comprising exposing the cell to an effective amount of Pilosulin 1 shown in the figure, an active portion thereof, or a functionally equivalent amino acid sequence thereof, such that the growth of the cell is inhibited.

La présente invention concerne un polypeptide isolé, qui présente une activité cytotoxique et qui comprend, soit la séquence d'acides aminés de la Pilosuline 1 représentée à la Figure 1, soit l'une de ses séquences d'acides aminés fonctionnellement équivalente. L'invention concerne également une technique d'inhibition de la croissance cellulaire consistant à exposer la cellule à une quantité suffisante, soit de la Pilosuline représentée à la Figure 1, soit de l'une de ses séquences d'acides aminés fonctionnellement équivalente, et ce, de façon à inhiber la croissance cellulaire.

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