Use of histamine for elevating blood histamine levels

Details Use of histamine for elevating blood histamine levels Use of histamine for elevating blood histamine levels

A - Human Necessities

61

K

A61K 31/415 (2006.01) A61K 31/417 (2006.01)

Patent

CA 2310255

Methods for obtaining beneficial stable levels of circulating histamine are disclosed for use in methods for enhancing natural killer cell cytotoxicity and for elevating histamine levels in individuals in need thereof. In such methods, a beneficial level of circulating histamine is attained and an agent whose ability to enhance natural killer cell cytotoxicity is augmented by histamine is administered. Alternatively, stable beneficial levels of circulating histamine can be attained in subjects receiving chemotherapy or antiviral treatment. The invention may also be employed in treatments combining histamine, agents which enhance natural killer cell cytotoxicity, and chemotherapeutic agents. Optimization of the delivery of histamine and substances which induce the release of endogenous histamine are also disclosed.

La présente invention concerne des procédés permettant d'atteindre dans la circulation des taux salutaires stables d'histamine. De tels procédés conviennent particulièrement pour des traitements destinés à renforcer la cytotoxicité naturelle des cellules tueuses et à augmenter le taux d'histamine chez des sujets justifiant d'un tel traitement. Pour atteindre un niveau salutaire d'histamine dans la circulation, le procédé consiste à administrer un agent dont l'aptitude à renforcer la cytotoxicité naturelle des cellules tueuses et elle-même augmentée par l'histamine. Selon une autre réalisation, l'invention permet à des sujets recevant un traitement chimiothérapique ou antiviral de retrouver dans la circulation des taux salutaires stables d'histamine. L'invention convient particulièrement également dans le cas de traitements combinant l'histamine, des agents renforçant la cytotoxicité naturelle des cellules tueuses, et des agents chimiothérapiques. L'invention concerne également une administration optimisée de l'histamine et des substances qui induisent la libération de l'histamine endogène.

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