Melanin concentrating hormone receptor ligands

Details Melanin concentrating hormone receptor ligands Melanin concentrating hormone receptor ligands

C - Chemistry, Metallurgy

07

D

C07D 295/096 (2006.01) A61K 31/495 (2006.01) A61P 3/04 (2006.01)

Patent

CA 2414198

Disclosed are compounds of formula (I), and the pharmaceutically acceptable salts thereof wheren Q, X, Y, Z, and R1 R9, and R12-R19 are defined herein. These compounds are selective modulators of MCH 1 receptors that are, therefore, useful in the treatment of a variety of metabolic, feeding, and sexual disorders. Methods of treatment of such disorders and well as packaged pharmaceutical compositions are also disclosed.

L'invention concerne des composants de formule (I) et des sels pharmaceutiquement acceptables de ceux-ci dans laquelle Q, X, Y, Z, et R¿1? R¿9?, et R¿12?-R¿19? sont définis dans ladite formule. Ces composants sont des modulateurs sélectifs de récepteurs MCH 1 qui sont, en conséquence, utilisés afin de traiter divers troubles sexuels, alimentaires et métaboliques. L'invention concerne également des procédés de traitement de ces troubles et des compositions pharmaceutiques.

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