Remedial agent for chronic articular rheumatism

A - Human Necessities – 61 – K

Patent

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Details

A61K 31/44 (2006.01) A61P 19/02 (2006.01)

Patent

CA 2443636

The present invention relates to an excellent remedial agent for chronic rheumatoid arthritis, comprising an aminostilbazole derivative represented by the following formula [1] or a salt thereof as an active ingredient: A-B-D-E [1] Wherein A represents heteroaryl or an oxide thereof, B represents ethenylene, D represents phenylene, E represents the formula: -N(R)SO2-G [wherein G represents phenyl, R represents hydrogen, alkyl, or -COR0 (R0 represents alkyl, alkoxy, aryloxy, 5- to 6-membered heteroaryl, heteroarylmethyl, aminoalkylene or cyclic amino alkylene)or the like].

L'invention porte sur un excellent agent thérapeutique pour rhumatisme articulaire chronique qui contient un dérivé d'aminostilbazole représenté par la formule (I) suivante : A-B-D-E, ou sur un sel de celui-ci utile comme ingrédient actif. Dans cette formule, A représente hétéroaryle ou un oxyde de celui-ci ; B représente éthénylène ; D représente phénylène ; et E représente N(R)SO2-G [G représentant phényle et R hydrogène, alkyle, -COR<0> (R<0> représente alkyle, alcoxy, aryloxy, hétéroaryle à 5 ou 6 éléments, hétéroarylméthyle, aminoalkylène ou aminoalkylène cyclique), etc.].

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