Mutant herpes simplex viruses and uses thereof

Details Mutant herpes simplex viruses and uses thereof Mutant herpes simplex viruses and uses thereof

C - Chemistry, Metallurgy

12

N

C12N 7/00 (2006.01) A61K 48/00 (2006.01) C07K 14/035 (2006.01) C12N 15/86 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2319669

The present invention provides a herpes simplex virus strain having a functional ICP27 gene and lacking at least a functional ICP4 gene and a functional ICP34.5 gene. It also provides the use of a herpes simplex virus strain which lacks at least a functional ICP4 gene and a functional ICP34.5 gene in the treatment of disorders of, or injuries to, the nervous system of a mammal.

La présente invention se rapporte à une souche de virus herpétique qui comporte un gène fonctionnel ICP27 mais à laquelle il manque au moins un gène fonctionnel ICP4 et un gène fonctionnel ICP34.5. L'invention se rapporte également à l'utilisation d'une souche de virus herpétique à laquelle il manque au moins un gène fonctionnel ICP4 et un gène fonctionnel ICP34.5 et qui est destinée au traitement de troubles, ou de blessures, affectant le système nerveux d'un mammifère.

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