Modified vitamin k-dependent polypeptides

Details Modified vitamin k-dependent polypeptides Modified vitamin k-dependent polypeptides

C - Chemistry, Metallurgy

12

N

C12N 9/64 (2006.01) A61K 38/48 (2006.01) A61P 7/02 (2006.01) C12N 5/10 (2006.01) C12N 15/55 (2006.01) C12N 15/57 (2006.01) C12N 15/85 (2006.01)

Patent

CA 2307175

The invention provides vitamin k-dependent polypeptides with enhanced membrane binding affinity. These polypeptides can be used to modulate clot formation in mammals. Methods of modulating clot formation in mammals are also described.

L'invention concerne des polypeptides dépendants de la vitamine k qui présentent une meilleure affinité de liaison à la membrane. Ces polypeptides peuvent être utilisés pour moduler la formation des caillots chez le mammifère. L'invention traite également de procédés de formation de caillots chez le mammifère.

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