Dipyrido/3,2-b:2'3'-e//1,4/oxazepin (and...

Details Dipyrido/3,2-b:2'3'-e//1,4/oxazepin (and... Dipyrido/3,2-b:2'3'-e//1,4/oxazepin (and...

C - Chemistry, Metallurgy

07

D

167/209, 260/238

C07D 498/14 (2006.01) A61K 31/55 (2006.01) C07D 513/14 (2006.01)

Patent

CA 2024055

25771-564 ABSTRACT Disclosed are novel dipyrido[3,2-b:2',3' e][1,4]- oxazepin(and thiazepin)-6(5H)-ones and -thiones of formula I: Image (I) in which X is oxygen or sulfur, Z is oxygen or sulfur, R1 is, for example, C1-C5-alkyl, R2 is hydrogen, methyl, ethyl, halogen, nitro or amino, R3, R5 and R7 is hydrogen, methyl or halogen, with the proviso that at least two of R5, R6 and R7 is hydrogen, R4 is, for example, hydrogen or C1-C4-alkyl, R6 is hydrogen, methyl, halogen or amino. The compounds of formula I possess inhibitory activity against HIV-1 reverse transcriptase and are useful in the prevention or treatment of AIDS.

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