C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
167/211, 260/251
C07D 403/06 (2006.01) A61K 31/505 (2006.01) A61K 31/535 (2006.01) C07D 239/36 (2006.01) C07D 239/46 (2006.01) C07D 239/52 (2006.01) C07D 239/54 (2006.01) C07D 239/56 (2006.01) C07D 239/91 (2006.01) C07D 403/10 (2006.01) C07D 405/00 (2006.01) C07D 413/14 (2006.01) C07D 471/04 (2006.01)
Patent
CA 2020370
4-17653/+ Novel pyrimidine derivatives Abstract Compounds of the formula Image (I) their tautomers and salts, in which Z is 0, S or N(R) and R is hydrogen or an aliphatic hydrocarbon radical; R1 is an unsubstituted or substituted aliphatic hydrocarbon radical, a cycloaliphatic or araliphatic hydrocarbon radical or an aromatic radical; R2 and R3, independently of one another, are halogen, acyl, an aromatic radical, unsubstituted or substituted amino, or carboxyl which, if desired, may be esterified or amidated; or R2 is -Zl-R'2 and R3 is -Z2-R'3, Z1 and Z2 independently of one another being a bond, O or S(O)n and n being 0, 1 or 2, and R'2 and R'3 independently of one another being hydrogen, an araliphatic or aliphatic hydrocarbon radical, the latter being unsubstituted or substituted and, if desired, interrupted by -O- or -S(O)n-, n being 0, 1 or 2; or R2 and R3 together are propylene or butylene or are the partial structure of the formula -CH=CH-CH=CH-, in which, if desired, one or two of the methyne groups are replaced by -N=; R4 is a group of the formula Image (Ia) in which Alk is a divalent aliphatic hydrocarbon; R5 is COOH, SO3H, haloalkanesulfamoyl, PO2H2, PO3H2 or 5-tetrazolyl; the rings A and B or the (hetero)aromatic ring jointly formed by R2 and R3 are, independently of one another, unsubstituted or substituted, can be used, for example, as phannaceutical activeingredients.
Buhlmayer Peter
Herold Peter
Ag Ciba-Geigy
Fetherstonhaugh & Co.
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