N-aminocarbamates related to physostigmine, a process for...

C - Chemistry – Metallurgy – 07 – D

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C07D 487/04 (2006.01) A61K 31/33 (2006.01)

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CA 2026381

- 1 - HOE 89/S 029 ABSTRACT N-Aminocarbamates Related to Physostigmine, a process for their preparation and their use as medicaments The present invention relates to compounds of the formula I, Image (I) where X is hydrogen, halogen or loweralkyl; and R1, R2 and R3 are each independently hydrogen, loweralkyl, cycloalkyl, arylloweralkyl or aryl, or alternatively the group -NR2R3 taken as a whole constitutes Image , Image or Image , R4 being hydrogen or loweralkyl and a process for their preparation. The compounds of the invention show central cholinergic innervative properties for treating various memory dysfunctions and can, therefore, be used as medicaments.

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