Dual function compounds and uses thereof

Details Dual function compounds and uses thereof Dual function compounds and uses thereof

C - Chemistry, Metallurgy

07

D

C07D 401/12 (2006.01) A61K 31/06 (2006.01) A61K 31/275 (2006.01) A61K 31/47 (2006.01) A61K 31/495 (2006.01) A61K 31/496 (2006.01) A61K 31/55 (2006.01) C07C 39/23 (2006.01) C07C 205/25 (2006.01) C07C 255/52 (2006.01) C07D 211/22 (2006.01) C07D 221/18 (2006.01) C07D 223/14 (2006.01) C07D 295/04 (2006.01) C07D 295/088 (2006.01) C07D 295/13 (2006.01) C07D 295/15 (2006.01) C07D 495/04 (2006.01)

Patent

CA 2528538

Dual action compounds are provided that are inhibitors of catechol- omethyltransferase (COMT) enzyme and are also partial agonists or antagonists of the D2 receptor, or agonists of the D1 receptor, or interact in these ways with both D1 and D2 receptors. Use of the compounds for treating neuropsychiatric disorders, particularly schizophrenia and mild cognitive impairment, is also described.

L'invention concerne des composés à action duale qui sont des inhibiteurs de l'enzyme de la catéchol-o-méthyltransférase (COMT) et qui constituent également des agonistes ou antagonistes partiels du récepteur D2 ou des agonistes du récepteur D1, ou qui interagissent de ces façons avec les récepteurs D1 et D2. Cette invention a aussi trait à l'utilisation des composés dans le traitement de troubles neuropsychiatriques, notamment, la schizophrénie et la déficience cognitive légère.

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